Monday, December 12, 2011

Mediators involved in anxiety disorder

Anxiety disorder is one of the most common mental disorders in the United States. There are different types of this disease, such as obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD) and posttraumatic stress disorder (PTSD). There are several reasons for anxiety disorders. Mostly, this is due to abnormal levels of certain chemicals that are known as neurotransmitters in the brain.
The brain continuously produces neurotransmitters that balance mood levels and keep them stable. When the mood levels are not stable, one is confronted with mood problems such as anxiety, stress and depression. Anxiety is also often seen as a sign of depression. Most of these mood disorders can be treated with various drugs. Nevertheless, it is important to consult a physician before taking any medication.
Serotonin is one of the chemicals that play an important role in maintaining the level of stress. Reduced levels of serotonin, as well as reducing the activity of this neurotransmitter can lead to anxiety, according to the American surgeon. If an anxiety disorder is associated with low levels of serotonin, it can be treated with selective serotonin reuptake inhibitors (SSRIs). In fact, these drugs is better than cure for people suffering from obsessive-compulsive disorder and post traumatic stress disorder.
Gamma amino butyric, or GABA, is a neurotransmitter, which has a calming effect on people. As serotonin deficiency in the neurotransmitter can cause anxiety. For the treatment of low levels of GABA, benzodiazepines are often prescribed. These drugs bind to GABA receptors and to increase the inhibitory neurotransmitter response. As a result, people get quick relief from anxiety. However, these drugs are not designed for prolonged use because they can be addictive.
Norepinephrine another neurotransmitter that can cause anxiety, if not found the right levels. This neurotransmitter is also known as nonadrenaline. This man excites and prepares him / her on the flight or fight response. When the body perceives stress, a neurotransmitter released adrenaline gland. However, if a person is in a state of chronic stress, norepinephrine always produced in the adrenal glands and the body is constantly in a state of flight or fight response. As a result, people are always stressed and nervous. This type of anxiety disorder can be treated with SNRIs, or serotonin and norepinephrine reuptake inhibitors. These drugs are approved by the U.S. FDA for the treatment of depression, but they can also be used for anxiety disorders, according to the Mayo Clinic. Some of the side effects of these drugs include dry mouth, tremor, nausea and insomnia.
Corticotropin-releasing hormone (CRH) plays a very important role in the management of stress disorders, according to the Surgeon General of the United States. CRH released in increased quantities in the case of anxiety disorder. An article published in 2008 in the European Journal of Pharmacology claims that drugs designed CRH receptors in the cells may be crucial for effective treatment of depression and other anxiety disorders.

Wednesday, September 28, 2011

Some Antidepressants From Blood Thinners May Pose a Risk for Patients With Heart Disease

Heart attack patients who take both choosy serotonin reuptake inhibitor antidepressants and antiplatelet drugs such as aspirin or Plavix cause a higher risk for bleeding than those who annihilate anti-clotting drugs not, a new study finds. Commonly prescribed SSRIs cover Zoloft, Prozac, Paxil, Lexapro and the buy Valium online.
Antiplatelet drugs arrest blood cells from sticking together and forming a blood clot. Sincerity attack patients are commonly prescribed antiplatelet group therapy to reduce their risk of another core attack. But there's an increased chance of bleeding, which increases coequal further when certain other drugs are bewitched at the same time.
 It so happens that uncountable heart attack patients be undergoing depression symptoms and are prescribed antidepressants, celebrated the researchers at McGill University in Montreal. "We're in any case concerned about how other medicine clout interact with the medicines we be aware are essential to heart health and betterment after heart attack," said Dr. Kirk Garratt, clinical pilot of interventional cardiovascular research at Lenox Hill Polyclinic in New York City.
"Although SSRIs are in use accustomed to in only a few cardiac patients, culture that SSRIs can increase jeopardy of bleeding complications could be suffering with important implications for how we care for patients after stents and other heartlessness procedures."
In the Canadian analysis, the researchers looked at more than 27,000 core attack patients, aged 50 and older, and create that patients taking aspirin or Plavix solitarily had a similar risk of bleeding. But alluring an SSRI antidepressant and aspirin increased the risk of bleeding by 42 percent, and fetching an SSRI with both aspirin and clopidogrel (dual antiplatelet treatment) increased the risk by 57 percent. Bleeding included gastrointestinal bleeding, hemorrhagic thrombosis or other bleeding that required hospitalization or occurred in the sanatorium during treatment.
The researchers also initiate that the risk of bleeding was deign in women and in patients who had angioplasty after their sensibility attack. The study appears Sept. 26 in the Canadian Medical Relationship Journal. "Ultimately, clinicians requirement weigh the benefits of SSRI treatment against the risk of bleeding in patients with outstanding depression following acute myocardial infarction," the researchers wrote in a weekly news release. They urged doctors to be vigilant when buy generic valium to nerve attack patients on antiplatelet psychoanalysis.